Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis

Candida albicans secreted aspartyl proteinases (Saps) are considered virulence-associated factors. Several members of the Sap family were claimed to play a significant role in the progression of candidiasis established by the hematogenous route. This assumption was based on the observed attenuated virulence of sap-null mutant strains. However, the exclusive contribution of SAP genes to their attenuated phenotype was not unequivocally confirmed, as the Ura status of these mutant strains could ...

T cells in mesenteric and subcutaneous adipose tissue of Holstein-Friesian cows

The importance of immune cells present in the adipose tissue to metabolic homeostasis has been increasingly recognized. Nevertheless, in bovines few studies have so far addressed the immune cell populations resident in this tissue. Here we developed an eight-colour flow cytometry panel to address T cell populations present in bovine adipose tissue. Our results showed that gamma dT cells, CD4(+) and CD8(+) CD3(+) non-gamma dT cells, as well as NK cells, are present in the mesenteric and subcut...

Epigenetic regulation of epilepsy-related signalling pathways and its impact on epileptogenesis

17α-Ethinylestradiol and atorvastatin effects in liver and blood-related parameters of juvenile brown trout