Peripherally administered melanocortins induce mice fat browning and prevent obesity
Background/objectives The browning of white adipose tissue (WAT) has been in the spotlight during the last years, becoming an attractive approach to combat obesity. Melanocortin neuropeptides, such as -melanocyte-stimulating hormone (alpha-MSH), are well-known regulators of appetite at the central nervous system, but its role in adipocyte metabolism is poorly elucidated. This study sought to verify if alpha-MSH can induce transdifferentiation of white to brown/beige adipocytes and to determin...
