Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/151584
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dc.creatorGouveia, R
dc.creatorCruz, VT
dc.creatorAlmeida, L
dc.date.accessioned2023-08-02T09:07:39Z-
dc.date.available2023-08-02T09:07:39Z-
dc.date.issued2022
dc.identifier.issn2399-6641
dc.identifier.urihttps://hdl.handle.net/10216/151584-
dc.description.abstractBackground/Aims Clinical trials are fundamental for the development of new medicines and patient participation is based on free consent. Our study sought to identify psychological characteristics that may influence patient willingness to participate in a clinical trial. Methods A total of 100 participants were invited to participate with 80% positive response rate. The psychological characteristics of each patient were evaluated using the following validated psychometric scales: Self-Efficacy Scale, Curiosity, Exploration Inventory-Trait, Social Support Satisfaction, State-Trait Anxiety Inventory and Social Avoidance and Distress, and Fear of Negative Evaluation. Results Patients who agreed to participate in the clinical trial were significantly younger than those who refused (p=0.028). There were no differences in sex, lifestyle, employment status, monthly income or education. After adjusting for age and sex, patients who agreed to participate scored significantly higher in the following: self-efficacy total score (p<0.001), effectiveness in adversity (p<0.001), social effectiveness (p<0.001) and initiation and persistence (p<0.001); social support total score (p<0.001), family satisfaction (p=0.015), friendship satisfaction (p<0.001), social activities satisfaction (p=0.002) and intimacy (p<0.001); total curiosity score (p<0.001), absorption (p<0.001) and exploration (p<0.001). Compared with patients who agreed to participate, those who refused scored significantly higher for both state (p<0.001) and trait anxiety (p<0.001), fear of negative evaluation (p<0.001) and social avoidance and distress (p<0.001). Conclusions Patients who were willing to participate in clinical trials exhibited different psychological characteristics to patients who refused. Specifically, they were more curious and self-efficacious, less anxious and reported a higher level of social support than patients who declined to participate. Identifying characteristics that condition the individual's decision to participate in a clinical trial has important implications for the development of patient-focused communication strategies and improved recruitment approaches. ©
dc.description.sponsorshipThis work was supported by BlueClinical, Ltd.
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofBMJ Open Qual. 2022 Oct;11(4):e002044. doi: 10.1136/bmjoq-2022-002044.
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectclinical decision-making; community-based participatory research; informed consent; patient participation; randomised controlled trial
dc.titleSociodemographic and psychological characteristics influencing patients' willingness to participate in clinical trials
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoInstituto de Saúde Pública da Universidade do Porto
dc.identifier.doi10.1136/bmjoq-2022-002044
dc.relation.publisherversionhttps://bmjopenquality.bmj.com/content/11/4/e002044#block-system-main
Appears in Collections:ISPUP - Artigo em Revista Científica Internacional

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