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dc.creatorAlmeida, M.C.
dc.creatorResende, D.I.S.P.
dc.creatorda Costa, P.M.
dc.creatorPinto, M.M.M.
dc.creatorSousa E.
dc.identifier.issnISSN 0223-5234
dc.description.abstractAntimicrobial resistance has become a major threat to public health worldwide, as pathogenic micro- organisms are finding ways to evade all known antimicrobials. Therefore, the demand for new and effective antimicrobial agents is also increasing. Natural products have always played an important role in drug discovery, either by themselves or as inspiration for synthetic compounds. The marine envi- ronment is a rich source of bioactive metabolites, and among them, tryptophan-derived alkaloids stand out for their abundance and by displaying a variety of biological activities, with antimicrobial properties being among the most significant. This review aims to reveal the potential of marine alkaloids derived from tryptophan as antimicrobial agents. Relevant examples of these compounds and their synthetic analogues reported in the last de- cades are presented and discussed in detail, with their mechanism of action and synthetic approaches whenever relevant. Several tryptophan-derived marine alkaloids have shown potent and promising antimicrobial activ- ities, whether against bacteria, fungi, or virus. Synthetic approaches to many of the compounds have been developed and recent methodologies are proving to be efficient. Even though most of the studies regarding the antimicrobial activity are still preliminary, this class of compounds has proven to be worth of further investigation and may provide useful lead compounds for the development of antimicrobial agents. Overall, marine alkaloids derived from tryptophan are revealed as a valuable class of antimi- crobials and molecular modifications in order to reduce the toxicity of these compounds and additional studies regarding their mechanism of action are interesting topics to explore in the future.
dc.description.sponsorshipThis research was supported by national funds through FCT - Foundation for Science and Technology within the scope of UIDB/ 04423/2020, UIDP/04423/2020, and under the project PTDC/SAU- PUB/28736/2017 (reference POCI-01-0145-FEDER-028736), co- financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds, as well as CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019. M. C. A. acknowledges BYT þ scholarship to CIIMAR.
dc.publisherEuropean Journal of Medicinal Chemistry
dc.relation.ispartofEuropean Journal of Medicinal Chemistry xxx (xxxx) xxx
dc.subjectMarine alkaloids
dc.subjectMedicinal chemistry
dc.titleTryptophan derived natural marine alkaloids and synthetic derivatives as promising antimicrobial agents
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoCentro Interdisciplinar de Investigação Marinha e Ambiental
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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