Medicação associada à colite isquémica

Abstract

ABSTRACT Introduction: Ischemic colitis is one of the most common causes of gastrointestinal ischemia, affecting any segment of the colon and presenting with a variety of symptoms. Several risk factors can be associated with ischemic colitis and a variety of drugs have also been associated with ischemic colitis. The purpose of this review article is to identify these drugs and their relationship to ischemic colon disease. Methods: The research was conducted through PubMed using the MeSH terms "colon ischemia" and "ischemic colitis" individually, as well as in combination with several groups of drugs, to establish a relationship. The research gathered a total of 111 articles, including cross-references. Results/Discussion: According to research, several groups of drugs seem to be linked to ischemic colitis, based on a certain underlying pathophysiological mechanism, even though there is a lack of codification and most of the results come from case series studies and case reports. Groups of drugs such as constipation inducers, digitalis, hormonal therapies, immunomodulators, illicit agents, laxatives, NSAIDs, appetite suppressants, chemotherapeutic agents, decongestants and serotonergic agents have proven to induce ischemic colitis. Conclusion: Pharmacological therapy is thus related to ischemic colitis. Therefore, it is important for the clinician to consider ischemic colitis as a cause of abdominal pain, diarrhea, and bloody diarrhea so that, early on, is able to identify any precipitating or associated drug, confirms the diagnosis and proceeds with the treatment appropriately. Keywords: Pharmacologically induced ischemic colitis; ischemic colitis; physiopathological relationship