Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/127424
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dc.creatorGener, P-
dc.creatorSeras-Franzoso, J-
dc.creatorCallejo, P-
dc.creatorAndrade, F-
dc.creatorRafael, D-
dc.creatorMartínez, F-
dc.creatorMontero, S-
dc.creatorArango, D-
dc.creatorSayós, J-
dc.creatorAbasolo, I-
dc.creatorSchwartz, S-
dc.date.accessioned2020-06-15T10:52:22Z-
dc.date.available2020-06-15T10:52:22Z-
dc.date.issued2018-
dc.identifier.issn1687-9678-
dc.identifier.urihttps://hdl.handle.net/10216/127424-
dc.description.abstractThere are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor. Likewise, cancer cells can switch between epithelial and mesenchymal phenotypes via well-described transition (EMT/MET) that is thought to be crucial for tumor propagation. In this review, we discuss whether, and to which extend, the CSCs and mesenchymal cancer cells are overlapping phenomena in terms of mechanisms, origin, and implication for cancer treatment. As well, we describe the dynamism of both phenotypes and involvement of the tumor microenvironment in CSC reversion and in EMT.-
dc.description.sponsorshipThis work was partially supported by grants PI14/02079 and PI17/02242 from Fondo de Investigaciones Sanitarias (FIS) of Instituto Carlos III (ISCIII), cofinanced by the European Regional Development Fund (FEDER), and grant AC15/00092 (Target4Cancer project) from EuroNanoMed II to SS and grant 337/C/2013 (PENTRI project) from Fundació Marató TV3 (Catalonia, Spain) to IA. The Portuguese Science and Technology Foundation (FCT) supported FA with a postdoctoral grant (SFRH/BD/76270/2011). La Asociación Española Contra el Cáncer (AECC) supported 8 Stem Cells International JSF with a postdoctoral fellowship. Plan Estratégico de Investigación e Innovación en Salud (PERIS) supported FM.-
dc.language.isoeng-
dc.publisherHindawi-
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F76270%2F2011/PT-
dc.relation.ispartofStem Cells International, vol.2018:4516454-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.titleDynamism, sensitivity, and consequences of mesenchymal and stem-like phenotype of cancer cells-
dc.typeArtigo em Revista Científica Internacional-
dc.contributor.uportoInstituto de Investigação e Inovação em Saúde-
dc.identifier.doi10.1155/2018/4516454-
dc.relation.publisherversionhttps://www.hindawi.com/journals/sci/2018/4516454/-
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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