Utilize este identificador para referenciar este registo: https://hdl.handle.net/10216/120734
Autor(es): Leiro, V
Garcia, J
Tomás, H
Pêgo, AP
Título: The Present and the Future of Degradable Dendrimers and Derivatives in Theranostics
Editor: American Chemical Society
Data de publicação: 2015
Resumo: Interest in dendrimer-based nanomedicines has been growing recently, as it is possible to precisely manipulate the molecular weight, chemical composition, and surface functionality of dendrimers, tuning their properties according to the desired biomedical application. However, one important concern about dendrimer-based therapeutics remains-the nondegradability under physiological conditions of the most commonly used dendrimers. Therefore, biodegradable dendrimers represent an attractive class of nanomaterials, since they present advantages over conventional nondegradable dendrimers regarding the release of the loaded molecules and the prevention of bioaccumulation of synthetic materials and subsequent cytotoxicity. Here, we present an overview of the state-of-the-art of the design of biodegradable dendritic structures, with particular focus on the hurdles regarding the use of these as vectors of drugs and nucleic acids, as well as macromolecular contrast agents.
Assunto: Animals
Biocompatible Materials/chemistry
Biocompatible Materials/metabolism
Contrast Media/chemistry
Contrast Media/metabolism
Drug Delivery Systems/methods
Gene Transfer Techniques
Magnetic Resonance Imaging/methods
Nucleic Acids/administration & dosage
Pharmaceutical Preparations/administration & dosage
Theranostic Nanomedicine/methods
URI: https://hdl.handle.net/10216/120734
Fonte: Bioconjugate Chemistry, vol. 26(7), p. 1182-1197
Informação Relacionada: info:eu-repo/grantAgreement/FCT/3599-PPCDT/112428/PT
Tipo de Documento: Artigo em Revista Científica Internacional
Condições de Acesso: openAccess
Licença: https://creativecommons.org/licenses/by-nc/4.0/
Aparece nas coleções:I3S - Artigo em Revista Científica Internacional

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
ThePresentandtheFutureofDegradableDendrimersandDerivativesinTheranostics.pdf1.36 MBAdobe PDFThumbnail

Este registo está protegido por Licença Creative Commons Creative Commons