Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/120476
Author(s): | Kumla D. Pereira J.A. Dethoup T. Gales L. Freitas-Silva J. Costa P.M. Lee M. Silva A.M.S. Sekeroglu N. Pinto M.M.M. Kijjoa A. |
Title: | Chromone derivatives and other constituents from cultures of the marine sponge-associated fungus penicillium erubescens KUFA0220 and their antibacterial activity |
Publisher: | MDPI |
Issue Date: | 2018 |
Abstract: | A previously unreported chromene derivative, 1-hydroxy-12-methoxycitromycin (1c), and four previously undescribed chromone derivatives, including pyanochromone (3b), spirofuranochromone (4), 7-hydroxy-6-methoxy-4-oxo-3-[(1E)-3-oxobut-1-en-1-yl]-4H-chromene-5-carboxylic acid (5), a pyranochromone dimer (6) were isolated, together with thirteen known compounds: β-sitostenone, ergosterol 5,8-endoperoxide, citromycin (1a), 12-methoxycitromycin (1b), myxotrichin D (1d), 12-methoxycitromycetin (1e), anhydrofulvic acid (2a), myxotrichin C (2b), penialidin D (2c), penialidin F (3a), SPF-3059-30 (7), GKK1032B (8) and secalonic acid A (9), from cultures of the marine sponge- associated fungus Penicillium erubescens KUFA0220. Compounds 1a-e, 2a, 3a, 4, 7-9, were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. Only 8 exhibited an in vitro growth inhibition of all Gram-positive bacteria whereas 9 showed growth inhibition of methicillin-resistant Staphyllococus aureus (MRSA). None of the compounds were active against Gram-negative bacteria tested. © 2018 MDPI. All Rights Reserved. |
Subject: | 1 hydroxy 12 methoxycitromycin 12 methoxycitromycetin 7 hydroxy 6 methoxy 4 oxo 3 [3 oxobut 1 en 1 yl] 4h chromene 5 carboxylic acid anhydrofulvic acid beta sitostenone chromone derivative citromycin ergosterol 5,8 endoperoxide gkk 1032 b myxotrichin C myxotrichin D penialidin D penialidin F pyanochromone pyranochromone dimer secalonic acid A spf 3059 30 spirofuranochromone unclassified drug antiinfective agent chromone derivative antibacterial activity Article bacterial growth bacterial strain controlled study drug structure Enterococcus faecium fungal strain fungus culture growth inhibition in vitro study methicillin resistant Staphylococcus aureus minimum bactericidal concentration minimum inhibitory concentration nonhuman Penicillium Penicillium erubescens vancomycin resistant Enterococcus animal aquatic species bacterium chemistry drug effect fungus Penicillium sponge (Porifera) Animals Anti-Bacterial Agents Aquatic Organisms Bacteria Chromones Fungi Penicillium Porifera |
URI: | https://hdl.handle.net/10216/120476 |
Source: | Marine Drugs, vol. 16(8): md16080289 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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Kumla D_2018.pdf | 2.04 MB | Adobe PDF | View/Open |
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