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https://hdl.handle.net/10216/120297
Author(s): | Capitão A. Lyssimachou A. Castro L.F.C. Santos M.M. |
Title: | Obesogens in the aquatic environment: an evolutionary and toxicological perspective |
Publisher: | Elsevier: Creative Commons Licenses |
Issue Date: | 2017 |
Abstract: | The rise of obesity in humans is a major health concern of our times, affecting an increasing proportion of the population worldwide. It is now evident that this phenomenon is not only associated with the lack of exercise and a balanced diet, but also due to environmental factors, such as exposure to environmental chemicals that interfere with lipid homeostasis. These chemicals, also known as obesogens, are present in a wide range of products of our daily life, such as cosmetics, paints, plastics, food cans and pesticide-treated food, among others. A growing body of evidences indicates that their action is not limited to mammals. Obesogens also end up in the aquatic environment, potentially affecting its ecosystems. In fact, reports show that some environmental chemicals are able to alter lipid homeostasis, impacting weight, lipid profile, signaling pathways and/or protein activity, of several taxa of aquatic animals. Such perturbations may give rise to physiological disorders and disease. Although largely unexplored from a comparative perspective, the key molecular components implicated in lipid homeostasis have likely appeared early in animal evolution. Therefore, it is not surprising that the obesogen effects are found in other animal groups beyond mammals. Collectively, data indicates that suspected obesogens impact lipid metabolism across phyla that have diverged over 600 million years ago. Thus, a consistent link between environmental chemical exposure and the obesity epidemic has emerged. This review aims to summarize the available information on the effects of putative obesogens in aquatic organisms, considering the similarities and differences of lipid homeostasis pathways among metazoans, thus contributing to a better understanding of the etiology of obesity in human populations. Finally, we identify the knowledge gaps in this field and we set future research priorities. © 2017 Elsevier |
Subject: | Animals Aquatic ecosystems Biology Chemical contamination Chemicals Mammals Metabolism Nutrition Physiology Aquatic animals Endocrine disruption Evolution Lipid metabolisms Nuclear receptors Obesogens Aquatic organisms alkylphenol atrazine endocrine disruptor fibric acid derivative obesogen organophosphate organotin compound phthalic acid unclassified drug aquatic environment aquatic organism chemical compound endocrine disruptor evolution lipid metabolism physiology toxicology agnathan Amphibia annelid aquatic environment arthropod biodiversity cartilaginous fish Cephalochordata environmental exposure evolution human lipid analysis lipid homeostasis lipid metabolism mollusc nematode nonhuman obesity pathophysiology priority journal protein function Review signal transduction taxonomy teleost Urochordata weight Animalia Mammalia Metazoa |
URI: | https://hdl.handle.net/10216/120297 |
Source: | Environment International, vol. 106, p. 153-169 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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Capitao A_2017.pdf | 1.48 MB | Adobe PDF | View/Open |
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