Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10216/115857
Autor(es): | Magda S. S. Moutinho Sofia Aragão Diogo Carmo Fátima Casaca Sandra Silva Joana Ribeiro Hugo Sousa Isabel Pires Felisbina Queiroga Bruno Colaço Rui Medeiros Paula A. Oliveira Carlos Lopes Margarida M. S. M. Bastos Rui M. Gil da Costa Oliveira |
Título: | Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice |
Data de publicação: | 2018 |
Resumo: | Aim: Cyclo-oxygenase-2 (COX2) plays a prominent role in carcinogenesis. This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. Materials and Methods: Six-week - old FVB/n mice were supplemented with rutin or curcumin for 24 weeks: HPV16(-/-) no treatment, n=12; HPV16(+/-) no treatment, n=13; HPV16(+/-) rutin, n=12; HPV16(+/-) curcumin, n=13. HPV16-induced skin lesions and their inflammatory infiltrates were studied histologically. COX2 expression was assessed immunohistochemically. Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). Curcumin led to dermal and epidermal scores of 10.5 and 4.5. Both compounds reduced leukocytic infiltration, but neither prevented epidermal dysplasia. Conclusion: COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals, reducing tumor-associated inflammation. However, this was not sufficient to block carcinogenesis, calling for additional studies focused on combination therapies. |
URI: | https://hdl.handle.net/10216/115857 |
Informação Relacionada: | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE |
Tipo de Documento: | Artigo em Revista Científica Internacional |
Condições de Acesso: | restrictedAccess |
Aparece nas coleções: | FEUP - Artigo em Revista Científica Internacional |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
289327.pdf Restricted Access | 276.72 kB | Adobe PDF | Request a copy from the Author(s) |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.