Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/114698
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Fontes-Carvalho, R | |
dc.creator | Gonçalves, A | |
dc.creator | Severo, M | |
dc.creator | Lourenço, P | |
dc.creator | Rocha-Gonçalves, F | |
dc.creator | Bettencourt, P | |
dc.creator | Leite-Moreira, A | |
dc.creator | Azevedo, A | |
dc.date.accessioned | 2018-08-27T11:34:50Z | - |
dc.date.available | 2018-08-27T11:34:50Z | - |
dc.date.issued | 2015 | |
dc.identifier.issn | 0167-5273 | |
dc.identifier.uri | http://hdl.handle.net/10216/114698 | - |
dc.description.abstract | Background: Obesity has been associated with subclinical diastolic dysfunction and increased risk of heart failure. Our aims were to evaluate the age- and sex-specific role of total and abdominal adiposity on diastolic function and to assess the direct and indirect pathophysiological mechanisms involved in this association. Methods and results: Within a population-based study (EPIPorto), a total of 1063 individuals aged ≥ 45 years (62% female; 62.4 ± 10.6 years) were evaluated using echocardiography, anthropometrics, electrical bioimpedance and blood tests. Diastolic function was assessed with using EAE/ASE consensus criteria. Worse diastolic function grades were associated with increased BMI, fat mass % and waist-to-height ratio (p for trend < 0.001). The inverse association between adiposity and diastolic function was stronger in men and in the younger population. In multivariate analysis, waist-to-height ratio (per cm/cm) was associated with reduced E′ velocity (adjusted β: − 14.4; 95% CI: − 21.1 to − 7.6; p < 0.001) and increased E/E′ ratio (adjusted β: 9.7, 95% CI: 5.4–10.0; p < 0.001), among men < 65 years. Both direct and indirect mechanisms were involved in the E′ velocity decrease by waist-to-height ratio in participants < 65 years. The effect was mainly direct in men (81.3%), while it was mostly indirect in women, through systolic blood pressure (50.8%) and inflammation (15.1%). Conclusions: Adiposity, especially abdominal, was associated with worse diastolic function. This association was more important in men and in the younger population. The causal mechanisms involved were sex-specific, with mostly direct effects among men and blood-pressure-mediated among women. | |
dc.language.iso | eng | |
dc.relation.ispartof | Int J Cardiol, vol. 191, p. 64-70 | |
dc.rights | openAccess | |
dc.subject | Diastole | |
dc.subject | Obesity | |
dc.subject | Waist circumference | |
dc.title | Direct, inflammation-mediated and blood-pressure-mediated effects of total and abdominal adiposity on diastolic function: EPIPorto study | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Instituto de Saúde Pública | |
dc.identifier.doi | 10.1016/j.ijcard.2015.04.250 | |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0167527315009845?via%3Dihub | |
Appears in Collections: | ISPUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FontesCarvalho2015.pdf | 321.95 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.