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Author(s): Alves, NL
Takahama, Y
Ohigashi, I
Ribeiro, AR
Baik, S
Anderson, G
Jenkinson, WE
Title: Serial progression of cortical and medullary thymic epithelial microenvironments.
Publisher: Wiley-VCH Verlag
Issue Date: 2014
Abstract: Thymic epithelial cells (TECs) provide key instructive signals for T-cell differentiation. Thymic cortical (cTECs) and medullary (mTECs) epithelial cells constitute two functionally distinct microenvironments for T-cell development, which derive from a common bipotent TEC progenitor. While seminal studies have partially elucidated events downstream of bipotent TECs in relation to the emergence of mTECs and their progenitors, the control and timing of the emergence of the cTEC lineage, particularly in relation to that of mTEC progenitors, has remained elusive. In this review, we describe distinct models that explain cTEC/mTEC lineage divergence from common bipotent progenitors. In particular, we summarize recent studies in mice providing evidence that mTECs, including the auto-immune regulator(+) subset, derive from progenitors initially endowed with phenotypic properties typically associated with the cTEC lineage. These observations support a novel "serial progression" model of TEC development, in which progenitors serially acquire cTEC lineage markers, prior to their commitment to the mTEC differentiation pathway. Gaining a better understanding of the phenotypic properties of early stages in TEC progenitor development should help in determining the mechanisms regulating cTEC/mTEC lineage development, and in strategies aimed at thymus reconstitution involving TEC therapy.
Subject: Animals
Cell Communication/immunology
Cell Differentiation
Cell Lineage
Epithelial Cells/immunology
Lymphoid Progenitor Cells/immunology
Models, Immunological
T-Lymphocyte Subsets/immunology
T-Lymphocytes, Regulatory/immunology
Thymus Gland/immunology
Source: European journal of immunology, vol. 44(1), p. 16-22
Related Information: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/110116/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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