Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/114505
Author(s): | Vale, A Cabanes, D Sousa, S |
Title: | Bacterial Toxins as Pathogen Weapons Against Phagocytes |
Publisher: | Frontiers Research Foundation |
Issue Date: | 2016 |
Abstract: | Bacterial toxins are virulence factors that manipulate host cell functions and take over the control of vital processes of living organisms to favor microbial infection. Some toxins directly target innate immune cells, thereby annihilating a major branch of the host immune response. In this review we will focus on bacterial toxins that act from the extracellular milieu and hinder the function of macrophages and neutrophils. In particular, we will concentrate on toxins from Gram-positive and Gram-negative bacteria that manipulate cell signaling or induce cell death by either imposing direct damage to the host cells cytoplasmic membrane or enzymatically modifying key eukaryotic targets. Outcomes regarding pathogen dissemination, host damage and disease progression will be discussed. |
Subject: | Bacterial exotoxin Immunomodulation Innate immune response Macrophages Neutrophil Phagocyte |
URI: | http://hdl.handle.net/10216/114505 |
Source: | Frontiers in microbiology, vol. 7:42 |
Related Information: | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/129800/PT info:eu-repo/grantAgreement/FCT/3599-PPCDT/137216/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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Vale et al 2017 Frontiers in Microbiology.pdf | 3.08 MB | Adobe PDF | View/Open |
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