Utilize este identificador para referenciar este registo: https://hdl.handle.net/10216/111839
Autor(es): Rodrigues, JG
Balmaña, M
Macedo, JA
Poças, J
Fernandes, Â
Freitas-Junior, JCM
Pinho, SS
Gomes, J
Magalhães, A
Gomes, C
Mereiter, S
Reis, CA
Título: Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis
Editor: Elsevier
Data de publicação: 2018
Resumo: Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate multi-step process that requires the acquisition of several cancer cell features, including the modulation of tumour cell migration, adhesion, invasion, and immune evasion. Changes in the cellular glycosylation are associated with malignant transformation of cancer cells, tumour progression and ultimately, metastasis formation. Glycans have major impact on cellular signalling and on the regulation of tumour cell-cell adhesion and cell-matrix interaction. Glycans drive the interplay between the cancer cells and the tumour microenvironment. In this review, we summarize the roles of glycan alterations in tumour progression, such as acquisition of oncogenic features due to modulation of receptor tyrosine kinases, proteoglycans, cadherins and integrins. We also highlight the importance of key glycan binding proteins such as selectins, siglecs and galectins, which are pivotal in the modulation of immune response. An overview on glycans as cancer biomarkers is also presented.
Assunto: Biomarkers
Glycosylation in cancer
Receptor tyrosine kinase
URI: http://hdl.handle.net/10216/111839
Série: Cellular immunology, vol. pii: S0008-8749(18)30121-7
Informação Relacionada: info:eu-repo/grantAgreement/FCT/5876/147342/PT
Tipo de Documento: Artigo em Revista Científica Internacional
Condições de Acesso: embargoedAccess
Licença: https://creativecommons.org/licenses/by-nc-nd/3.0/
Data Fim de Embargo: 2019-03-20
Aparece nas coleções:I3S - Artigo em Revista Científica Internacional

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