Qualidade óssea de ratas wistar em crescimento alimentadas com ração hiperlipídica

Abstract

The relationship between obesity and bonetissue remains contradictory, even after years ofinvestigation. The results are non-specific, particularlywhen it assessed the effect of high-fat diets inexperimental models. The aim of this study was toevaluate bone quality of wistar growing rats fed withhigh-fat diet. 20 post-weaning wistars rats were used inthis study. They were equally divided into two groups,PAD: rats fed with standard diet AIN-93 and HIP: ratsfed with a modified AIN-93 diet to contain 60% ofenergy as fat. The exposure period was 5 weeks. Therats were euthanized by overdose of anesthesia and,after autopsy and dissection, tibiae were analyzed whenthe Bone Mineral Density, Mechanical Strength andMicrostructural Analysis by Scanning ElectronMicroscopy. BMD was statistically higher in the HIPgroup compared to the PAD group. However, themechanical strength was statistically similar betweenthe two groups. Microarchitecture remained similarbetween the two groups observed by quantitativeanalysis. It was concluded, therefore, that althoughBMD was higher in the group fed high-fat diet, themechanical strength and bone microarchitectureremained intact after 5 weeks of exposure.