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dc.creatorManuela F. Frasco
dc.creatorGabriela M. Almeida
dc.creatorFilipe Santos Silva
dc.creatorMaria do Carmo Pereira
dc.creatorManuel A. N. Coelho
dc.description.abstractThe aim of this study was to develop a drug delivery system based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles for an efficient and targeted action of the proteasome inhibitor bortezomib against pancreatic cancer cells. The PLGA nanoparticles were formulated with a poloxamer, and further surface-modified with transferrin for tumor targeting. The nanoparticles were characterized as polymer carriers of bortezomib, and the cellular uptake and growth inhibitory effects were evaluated in pancreatic cells. Cellular internalization of nanoparticles was observed in normal and cancer cells, but with higher uptake by cancer cells. The sustained release of the loaded bortezomib from PLGA nanoparticles showed cytotoxic effects against pancreatic normal and cancer cells. Noteworthy differential cytotoxicity was attained by transferrin surface-modified PLGA nanoparticles since significant cell growth inhibition by delivered bortezomib was only observed in cancer cells. These findings demonstrate that the ligand transferrin enhanced the targeted delivery of bortezomib-loaded PLGA nanoparticles to pancreatic cancer cells. These in vitro results highlight the transferrin surface-modified PLGA nanoparticles as a promising system for targeted delivery of anticancer drugs. (c) 2014 Wiley Periodicals, Inc.
dc.relationinfo:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/QUI-BIQ/115449/2009/Distibuição de biomoleculas através de nanopartículas inorganica/organicas /BIONANO
dc.titleTransferrin surface-modified PLGA nanoparticles-mediated delivery of a proteasome inhibitor to human pancreatic cancer cells
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Engenharia
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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