Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10216/103262
Autor(es): | Anabela Borges Pedro Sousa Alexandra Gaspar Santiago Vilar Fernanda Borges Manuel Simões |
Título: | Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes |
Data de publicação: | 2017-01-31 |
Resumo: | Disruption of cell-cell communication or quorum sensing (QS) is considered a stimulating approach for reducing bacterial pathogenicity and resistance. Although several QS inhibitors (QSIs) have been discovered so far their clinical use remains distant. This problem can be circumvented by searching for QSI among drugs already approved for the treatment of different diseases. In this context, antibiotics have earned special attention. Whereas at high concentrations antibiotics exert a killing effect, at lower concentrations they may act as signaling molecules and as such can modulate gene expression. In this study, the antibiotic furvina was shown to be able to cause inhibition of the 3-oxo-C12-HSL-dependent QS system of Pseudomonas aeruginosa. Furvina interacts with the LasI/LasR system. The data were validated by modeling studies. Furvina can also reduce biofilm formation and decrease the production of QS-controlled virulence factors. |
Assunto: | Ciências da Saúde, Ciências da engenharia e tecnologias Health sciences, Engineering and technology |
Áreas do conhecimento: | Ciências da engenharia e tecnologias Engineering and technology |
URI: | https://hdl.handle.net/10216/103262 |
Informação Relacionada: | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE |
Tipo de Documento: | Artigo em Revista Científica Internacional |
Condições de Acesso: | restrictedAccess |
Aparece nas coleções: | FCUP - Artigo em Revista Científica Internacional FEUP - Artigo em Revista Científica Internacional |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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181384.pdf Restricted Access | Artigo original publicado | 2.08 MB | Adobe PDF | Request a copy from the Author(s) |
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