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Author(s): Sandra Rocha
Maria do Carmo Pereira
Manuel A. N. Coelho
Sílvia Castro Coelho
Petras Juzenas
Title: Functionalized gold nanoparticles for drug delivery
Issue Date: 2013
Abstract: Gold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug activity and the anticancer effects in human prostate cancer cells (Du-145) were evaluated. It was observed that gold nanoparticles, with small diameters (24 nm), at concentrations of 0.1 nM are not toxic for Du-145 cells. Finally, nanoparticle parameters were discussed and new ideas are proposed to optimize the anticancer properties of conjugated gold nanoparticles leading to a better delivery of the drug, minimizing the side effects.
Subject: Biotecnologia ambiental
Environmental biotechnology
Scientific areas: Ciências da engenharia e tecnologias::Biotecnologia ambiental
Engineering and technology::Environmental biotechnology
Source: 3rd Portuguese Bioengineering Meeting, ENBENG 2013 - Book of Proceedings
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/QUI-BIQ/115449/2009/Distibuição de biomoleculas através de nanopartículas inorganica/organicas /BIONANO
Document Type: Artigo em Livro de Atas de Conferência Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Livro de Atas de Conferência Internacional

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