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https://hdl.handle.net/10216/103111
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DC Field | Value | Language |
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dc.creator | Joana A. Loureiro | |
dc.creator | Rosa Crespo | |
dc.creator | Hans Börner | |
dc.creator | Pedro M. Martins | |
dc.creator | Fernando A. Rocha | |
dc.creator | Manuel Coelho | |
dc.creator | M. Carmo Pereira | |
dc.creator | Sandra Rocha | |
dc.date.accessioned | 2022-09-08T04:54:49Z | - |
dc.date.available | 2022-09-08T04:54:49Z | - |
dc.date.issued | 2014 | |
dc.identifier.issn | 2050-7518 | |
dc.identifier.other | sigarra:106052 | |
dc.identifier.uri | https://hdl.handle.net/10216/103111 | - |
dc.description.abstract | The aggregation of amyloid-beta peptide (Ab) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer's disease. We synthesized peptides containing fluorinated amino acids and studied their effect on the Ab aggregation. The peptides were based on the sequence LVFFD, in which valine was substituted by either 4,4,4-trifluorovaline or 4-fluoroproline, or the phenylalanine at position 3 was replaced by 3,4,5-trifluorophenylalanine. Our results demonstrate that fluorination of the hydrophobic residue valine or phenylalanine is effective in preventing the Ab aggregation. This study opens up the possibility of using new sequences based on fluorinated amino acids to inhibit the amyloid- fibril formation. | |
dc.language.iso | eng | |
dc.relation | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/Referência: PTDC/QUI-BIQ/102827/2008/Concepção de péptidos fluorados para inibição da agregação do péptido beta-amilóide e avaliação da sua actividade biológica/Referência: PTDC/QUI-BIQ/102827/2008 | |
dc.rights | restrictedAccess | |
dc.subject | Ciências Tecnológicas, Ciências da engenharia e tecnologias | |
dc.subject | Technological sciences, Engineering and technology | |
dc.title | Fluorinated beta-sheet breaker peptides | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Faculdade de Engenharia | |
dc.contributor.uporto | Instituto de Ciências Biomédicas Abel Salazar | |
dc.identifier.doi | 10.1039/c3tb21483d | |
dc.identifier.authenticus | P-009-ASR | |
dc.subject.fos | Ciências da engenharia e tecnologias | |
dc.subject.fos | Engineering and technology | |
Appears in Collections: | FEUP - Artigo em Revista Científica Internacional ICBAS - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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106052.pdf Restricted Access | Artigo original publicado | 1.19 MB | Adobe PDF | Request a copy from the Author(s) |
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