https://hdl.handle.net/10216/73089 Sat, 08 Aug 2026 02:42:22 GMT 2026-08-08T02:42:22Z https://hdl.handle.net/10216/174753 Title: Pharmacological therapies for neglected tropical diseases: a systematic review and evidence gap mapping Abstract: Background: Neglected tropical diseases (NTDs) comprise 21 endemic infections that affect over one billion people worldwide. This study mapped and identified evidence gaps regarding pharmacological therapies for all WHO-recognized NTDs. Methods: We systematically searched PubMed for systematic reviews (SRs) and randomized controlled trials (RCTs), and the ClinicalTrials. gov database for ongoing RCTs. Methodological quality was assessed using the AMSTAR-2 for SRs and the Cochrane Risk of Bias tool for RCTs. Data were synthesized into evidence and gap maps, and the distribution of evidence was analyzed according to quality. Results: Twenty-four maps were developed, including 74 SRs, 500 RCTs, and 70 ongoing clinical trials; of these, only seven SRs and 17 RCTs were rated as high quality or as having a low risk of bias, respectively. Trachoma exhibited the highest number of evidence gaps, while Buruli ulcer had the lowest. Taeniasis/cysticercosis presented the highest proportion (31.8%) of high-quality SRs, whereas Chagas disease showed the highest proportion of RCTs with a low risk of bias (18.4%). Conclusions: Significant gaps remain in the evidence regarding the efficacy and safety of pharmacological treatments for WHO-recognized NTDs. The currently available evidence is predominantly of low methodological quality and is often insufficient to support robust therapeutic conclusions, highlighting the urgent need for rigorously designed clinical trials. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10216/174753 2026-01-01T00:00:00Z https://hdl.handle.net/10216/175379 Title: Assistive technologies for medication self-management in people with disabilities: A systematic scoping review and evidence map Abstract: Background Medication self-management poses significant challenges for persons with disabilities. Although self-help devices and assistive technologies (ATs) have the potential to enhance autonomy and safety, the evidence supporting their effectiveness is fragmented. Objective To systematically map scientific literature on ATs that support medication use among individuals with vision disorders, hearing loss, or intellectual disabilities. Methods A systematic scoping review was conducted in accordance with the JBI and PRISMA-ScR guidelines. Six databases were searched for studies published since 2000 that evaluated ATs designed to support medication management in specified populations. Data were extracted in duplicate to classify the technologies, study designs, and outcomes. Results Of the 1147 identified records, 80 studies were included. Most of these studies addressed visual impairment (n = 41; 51.2%) and focused on electronic devices. The evidence base consisted primarily of small-scale observational studies. Only 23 studies (28.7%) evaluated outcomes, primarily user satisfaction or device performance. Only three studies assessed clinical outcomes such as medication errors or hospitalizations, and only ten (12.5%) reported cost analyses. Conclusions There is a critical gap between the technological innovation of ATs and their clinical validation. Despite the existence of numerous prototypes, there is a lack of robust evidence on the effectiveness, safety, and cost-effectiveness of ATs. Future research should use rigorous methods, such as randomized controlled trials and economic evaluations, to prove the clinical value of ATs in improving medication safety and accessibility for people with disabilities. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10216/175379 2026-01-01T00:00:00Z https://hdl.handle.net/10216/160028 Title: Effect of T2-T4 sympathicotomy in skin temperature of pediatric patients with hyperhidrosis: a thermographic follow-up. Abstract: [No abstract available] Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/160028 2024-01-01T00:00:00Z https://hdl.handle.net/10216/144275 Title: Patterns of street food purchase in cities from Central Asia (vol 9, 925771, 2022) [correction] Abstract: In the published article, there was an error in Figure 5 as published. The legend for the red bars was Industrial only and the legend for the green bars was Homemade and industrial.However, these legends weremistakenly switched. As such, the correct legend for the red bars is Homemade and industrial and the correct legend for the green bars is Industrial only. The corrected Figure 5 and its caption appear below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. (c) 2022 Sousa, Lança de Morais,Albuquerque, Gelormini, Casal, Pinho, Motta, Damasceno, Moreira, Breda, Lunet and Padrão. Sat, 01 Jan 2022 00:00:00 GMT https://hdl.handle.net/10216/144275 2022-01-01T00:00:00Z https://hdl.handle.net/10216/172341 Title: Subclinical renal tubular dysfunction in postmenopausal women exposed to low-level environmental cadmium Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/172341 2025-01-01T00:00:00Z https://hdl.handle.net/10216/137597 Title: Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis Abstract: BACKGROUND: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak. OBJECTIVES: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil. DESIGN AND SETTING: Systematic review and meta-analysis conducted at a Brazilian public university. METHODS: A search from index inception until May 2020 was conducted. Meta-analyses were performed using inverse variance for fixed models, with summary proportions calculation using Freeman-Tukey double arcsine (base case). Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. RESULTS: Our review identified 12 studies, comprising 1,316 participants, especially breastfeeding women. There was at least one quality weakness in all studies, mainly regarding sampling method (i.e. convenience sampling) and small sample size. The prevalence of vitamin C deficiency ranged from 0% to 40%. Only vitamin E deficiency was synthetized in meta-analyses, with mean prevalences of 6% regardless of the alpha-tocopherol cutoff in plasma, and 5% and 16% for cutoffs of < 1.6-12.0 mmol/l and < 16.2 mmol/l, respectively. The cumulative meta-analysis suggested that a trend to lower prevalence of vitamin E deficiency occurred in recent studies. CONCLUSIONS: Although the studies identified in this systematic review had poor methodological and reporting quality, mild-moderate vitamin C and E deficiencies were identified, especially in breastfeeding women. Thus, designing and implementing policies does not seem to be a priority, because the need has not been properly dimensioned among women of childbearing age in Brazil. Fri, 01 Jan 2021 00:00:00 GMT https://hdl.handle.net/10216/137597 2021-01-01T00:00:00Z https://hdl.handle.net/10216/169959 Title: Qué es la integración de la Farmacia Comunitaria en el Sistema de Salud? Abstract: [No abstract available] Sat, 01 Jan 2022 00:00:00 GMT https://hdl.handle.net/10216/169959 2022-01-01T00:00:00Z https://hdl.handle.net/10216/165666 Title: The International Collaboration of Pharmacy Journal Editors (ICPJE) formally constituted to foster quality around clinical and social pharmacy practice research publications Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/165666 2025-01-01T00:00:00Z https://hdl.handle.net/10216/166610 Title: The International Collaboration of Pharmacy Journal Editors (ICPJE) formally constituted to foster quality around clinical and social pharmacy practice research publications Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/166610 2025-01-01T00:00:00Z https://hdl.handle.net/10216/166609 Title: The International Collaboration of Pharmacy Journal Editors (ICPJE) formally constituted to foster quality around clinical and social pharmacy practice research publications Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/166609 2025-01-01T00:00:00Z https://hdl.handle.net/10216/165665 Title: The international collaboration of pharmacy journal editors (ICPJE) formally constituted to foster quality around clinical and social pharmacy practice research publications Abstract: [No abstract available] Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/165665 2025-01-01T00:00:00Z https://hdl.handle.net/10216/164473 Title: The International Collaboration of Pharmacy Journal Editors (ICPJE) formally constituted to foster quality around clinical and social pharmacy practice research publications Abstract: <jats:p>In summary, the ICPJE was born from an initial small group that met previously in Granada to advance the visibility and quality of research in clinical, social and administrative pharmacy practice. Even prior to its formal naming, the group had made progress recently, although it recognises the need to consolidate its work. The group is dedicated toward strengthening clinical, social and administrative pharmacy practice, not only as a discipline, but the entire profession, including the patients served by its clinicians and researchers. The ICPJE was founded by a select group of journals; but ultimately it is a group that is open to any other journal in the field. Each journal is represented by a vibrant group of individuals, including the editors and publishing companies. The ICPJE will be reaching out to various stakeholders seeking collaboration and insights from fellow scholars and practitioners throughout the world. </jats:p> Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/164473 2025-01-01T00:00:00Z https://hdl.handle.net/10216/164965 Title: Medicines for the management of overweight and obesity: A systematic review with network meta-analysis Abstract: To synthesize the evidence about pharmacologic treatment of obesity and overweight and to define the options with the best risk-benefit using the stochastic analysis of multicriteria acceptability (SMAA). The analysis addresses a systematic review (PROSPERO CRD42023423308) whose research was realized in PubMed, Scopus, and Web of Science. Randomized controlled trials were included, which verified the effects of sibutramine, orlistat, liraglutide, and semaglutide in patients with IMC >= 26 Kg/ m(2). The risk of bias analysis was performed with RoB 2.0 and the outcomes evaluated were weight loss and serious adverse events. A total of 102 studies with 45.047 participants were included. The network meta-analysis revealed that all the treatments were significantly more effective than the placebo in weight reduction. The use of semaglutide (especially 0.4 mg/day) was associated with a bigger weight loss in comparison to all the other treatments (p<0.05) and the analysis of SMAA showed a risk-benefit of 95%. Besides that, we suggest re-evaluating of sibutramine 10mg/day as a therapeutic option for patients without hypertension or cardiovascular diseases, and we demonstrate the modest weight loss promoted by orlistat 120mg, sibutramine 5mg, and liraglutide 1,8mg and advise against its use, once the benefits do not outweigh the risks. Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/164965 2025-01-01T00:00:00Z https://hdl.handle.net/10216/164939 Title: The International Collaboration of Pharmacy Journal Editors (ICPJE) formally constituted to foster quality around clinical and social pharmacy practice research publications Abstract: [No abstract available] Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/164939 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165352 Title: In situ assessment of neurophysiology and neuropathology in a zebrafish model of ALS Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/165352 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165351 Title: Effects of mutated ATP synthase on cell physiology and mitochondrial deubiquitinases in treating mitochondrial diseases Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/165351 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165269 Title: Strategies for enhancing the selectivity of quantum dot-based fluorometric methods Abstract: In recent decades, quantum dots (QDs) have emerged as highly efficient fluorophores, enabling the quantification of various species across diverse fields. However, their typically unspecific sensing mechanisms, arising from their high reactivity and propensity to establish nonspecific interactions, frequently lead to a lack of selectivity, which hinders their application in the analysis of complex samples. This review presents the state-of-the-art of the most commonly applied QD-based analytical approaches to circumvent these limitations and improve selectivity. Moreover, several interesting examples of surface modification, sample preparation, and chemometric tools are highlighted to demonstrate their potentialities and shortcomings. This review profiles the trends and perspectives to broaden the analytical application of QDs. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/165269 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165265 Title: Chemometric models for data processing in quantum dots-based photoluminescence methodologies Abstract: The appealing properties of quantum dots (QDs) have drawn the scientific community's attention, leading to extensive research on using these nanomaterials as sensing platforms for the detection and quantification of a variety of analytes in environmental, biological, pharmaceutical and food samples. Despite the multiple inventive strategies that can be used to develop efficient QDs-sensing schemes, the defiant reactivity of these nano -materials, and their propensity to establish non-specific interactions, has significantly restrained their utilisation in situations demanding high selectivity, as is the case of the quantification of analytes in samples with interfering species or complex matrices, and in multiplexed detection. Several approaches have been proposed to overcome these selectivity issues, among which the chemometric analysis of photoluminescent (PL) data acquired from QDs-based analytical methodologies can be highlighted.This review details the application of chemometric models in the characterization and optimization of QDs-based analytical procedures, as well as for the analysis of data obtained from QDs-based PL methodologies, discussing how they can be used to circumvent selectivity issues and pointing out the corresponding advantages and limitations. In this work, we provide insights not only about probe arrangement strategies that could be designed to obtain efficient QDs-based sensing platforms but also regarding the requirements that must be observed to select both the most suitable type of data and the most effective chemometric model to assure the objectives of the methodology. Related advantages, namely second and higher-order advantages, constraints, and application prospects are also discussed. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/165265 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165006 Title: Gadolinium and gadoteric acid's short-term impact on kidney function and lipid profile Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/165006 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165004 Title: Gadolinium and gadoteric acid exposure induce long-term down-regulation in erythroid-related genes Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/165004 2024-01-01T00:00:00Z