https://hdl.handle.net/10216/111647 Sat, 18 Jul 2026 09:49:59 GMT 2026-07-18T09:49:59Z https://hdl.handle.net/10216/168444 Title: Reply to Prof. Tiejuan Shao et al. Abstract: [No abstract available] Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/168444 2025-01-01T00:00:00Z https://hdl.handle.net/10216/166081 Title: Urgent request for pretomanid label expansion to align with WHO guidelines and improve treatment accessibility and efficacy Abstract: Pretomanid is a key anti-TB drug included in the WHO list of essential medications. The current EMA-approved label for pretomanid restricts its use to the regimen comprising bedaquiline, pretomanid and linezolid (BPaL) and only for extensively drug-resistant-TB or multidrug-resistant TB, “when antibiotics used for the latter form of TB do not work or cause unacceptable side effects.” This restricted use implies that the older, prolonged and poorly tolerated regimens remain the recommended treatment for most cases of drug-resistant TB. The authors, representing many respiratory groups and societies, call for the label expansion of pretomanid to align with global guidelines, allowing for broader use. Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/166081 2025-01-01T00:00:00Z https://hdl.handle.net/10216/166080 Title: Recruitment and retention in a multidomain intervention for post-TIA and minor stroke: turning challenges into lessons Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/166080 2025-01-01T00:00:00Z https://hdl.handle.net/10216/166079 Title: The importance of getting the dose right in the treatment of tuberculosis Abstract: Prescribing the optimal combination of anti-tuberculosis drugs at the right dose is a fundamental step to achieve successful treatment outcomes. To aid the decision, clinicians should consider multiple factors, such as body weight, age, results of drug susceptibility testing, risk of intolerance and potential drug-drug interactions. In this viewpoint, we outline different aspects of dose selection in the treatment of tuberculosis (TB) such as traditional pharmacokinetics/pharmacodynamics, population pharmacokinetics models, the importance of real-world evidence and clinical trial design in the development of shorter treatment regimens and the new TB drug pipeline. Therapeutic drug monitoring for rifampicin, linezolid and amikacin may significantly improve their risk-benefit profile promoting their responsible administration. Precision dosing of novel, repurposed or conventional TB drugs should ensure optimal efficacy, while minimising toxicity and the development of resistance. Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/166079 2025-01-01T00:00:00Z https://hdl.handle.net/10216/165746 Title: Detection of Rat Hepatitis E Virus in Pigs, Spain, 2023 Abstract: We identified rat hepatitis E virus (HEV) RNA in farmed pigs from Spain. Our results indicate that pigs might be susceptible to rat HEV and could serve as viral intermediaries between rodents and humans. Europe should evaluate the prevalence of rat HEV in farmed pigs to assess the risk to public health. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/165746 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165648 Title: Filling the Gap to Address Vaccine Hesitancy in Europe Abstract: [No abstract available] Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/165648 2025-01-01T00:00:00Z https://hdl.handle.net/10216/165126 Title: EAACI Clinical and Research Fellowship Program: Shaping the Future of Allergy and Clinical Immunology Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10216/165126 2025-01-01T00:00:00Z https://hdl.handle.net/10216/165008 Title: Skin barrier dysfunction associates with type 2 inflammatory diseases: Evidence from a birth cohort Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/165008 2024-01-01T00:00:00Z https://hdl.handle.net/10216/164755 Title: Immune Response Induced by SARS-CoV-2 Vaccines in Patients with Inflammatory Bowel Disease under Biologic Therapy Sat, 01 Jan 2022 00:00:00 GMT https://hdl.handle.net/10216/164755 2022-01-01T00:00:00Z https://hdl.handle.net/10216/164574 Title: Factors associated with patient delay in the diagnosis of TB – a study of health-seeking behaviour Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/164574 2024-01-01T00:00:00Z https://hdl.handle.net/10216/164565 Title: Editorial comments on "Multiarray screening identifies plasma proteins associated with Th17 cell differentiation and viral defense in coincident asthma and obesity" Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/164565 2024-01-01T00:00:00Z https://hdl.handle.net/10216/164564 Title: Barriers to TB detection in Portuguese prisons Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/164564 2024-01-01T00:00:00Z https://hdl.handle.net/10216/163852 Title: Viewpoint on WHO implementation guidance on tuberculosis infection prevention and control Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/163852 2024-01-01T00:00:00Z https://hdl.handle.net/10216/162436 Title: Serological evidence of antibodies to Flaviviridae in wild birds in Portugal Abstract: Emerging infectious diseases are a major threat to biodiversity and an important public health issue. Flaviviruses are the cause of several emerging vector-borne zoonotic arboviruses whose distribution is currently increasing in Europe. The evidence that West Nile virus (WNV) circulates in resident and migratory species has implications for both animal and public health and should therefore be studied in depth. USUTU (USUV), Bagaza (BAGV) and tick-borne encephalitis virus (TBEV) are other viruses that are beginning to spread more widely. An integrated surveillance program, namely in birds, is essential for reducing the risk of infection in human populations within the One Health principles. In the present study, wild birds admitted to wildlife rehabilitation centers in Portugal were sampled. Two hundred eight blood samples were assayed serologically for antibodies to flaviviruses by using a commercial ELISA kit. An overall seroprevalence of 19.6% (95% confidence interval [CI]: 13.7–26.7%) was observed. Antibodies against flaviviruses were detected in 13 (35.1%) different species of wild birds. Accipitriformes (26.7%; 95% CI: 18.5–36.2%) and Strigiformes (26.7%; 95% CI: 14.6–42.0%) were the orders with the highest seroprevalence rates recorded. There were no statistically significant differences (p = 0.725) between the geographical regions (NUTS II) studied, but a statistically significant difference (p = 0.017) was found between sex (male: 34.4%; female: 4.8%). A higher seroprevalence was detected in adults (32.1%) than in juvenile birds (9.3%) (p = 0.014), and age was considered a risk factor for flavivirus infection in wild birds (odds ratio 1.4; 95% CI: 0.5–4.0). More epidemiological studies are needed in Portugal since the actual spread of the genus Flavivirus throughout the country is unknown. © The Author(s) 2024. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10216/162436 2024-01-01T00:00:00Z https://hdl.handle.net/10216/159944 Title: Authors' reply to Page and Rafi Fri, 01 Jan 2016 00:00:00 GMT https://hdl.handle.net/10216/159944 2016-01-01T00:00:00Z https://hdl.handle.net/10216/159943 Title: After a quarter of century, reduction in Coronary Heart Disease Mortality bypassed young adult males in Portugal Sat, 01 Jan 2011 00:00:00 GMT https://hdl.handle.net/10216/159943 2011-01-01T00:00:00Z https://hdl.handle.net/10216/159942 Title: Chronic atrophic gastritis, intestinal metaplasia, helicobacter pylori virulence, IL1RN polymorphisms, and smoking in dyspeptic patients from Mozambique and Portugal Thu, 01 Jan 2009 00:00:00 GMT https://hdl.handle.net/10216/159942 2009-01-01T00:00:00Z https://hdl.handle.net/10216/159941 Title: Assessing the completeness of cancer registration using suboptimal death certificate information Sun, 01 Jan 2012 00:00:00 GMT https://hdl.handle.net/10216/159941 2012-01-01T00:00:00Z https://hdl.handle.net/10216/159940 Title: Alopecia in women submitted to childhood X-ray epilation for tinea capitis treatment Fri, 01 Jan 2010 00:00:00 GMT https://hdl.handle.net/10216/159940 2010-01-01T00:00:00Z https://hdl.handle.net/10216/159939 Title: Stool Isolation of Nocardia nova in Two Immunomodulated Patients with Inflammatory Bowel Diseases Fri, 01 Jan 2016 00:00:00 GMT https://hdl.handle.net/10216/159939 2016-01-01T00:00:00Z