https://hdl.handle.net/10216/26777 2026-07-10T14:59:32Z https://hdl.handle.net/10216/172964 Title: Aprendizagem colaborativa e responsabilidade social das universidades na prevenção do consumo de novas substâncias psicoativas 2025-01-01T00:00:00Z https://hdl.handle.net/10216/172959 Title: O papel do feedback dos estudantes na avaliação e inovação curricular: uma experiência em ciências farmacêuticas 2025-01-01T00:00:00Z https://hdl.handle.net/10216/172079 Title: Hygiene challenges in foodservice units: biocide efficacy and bacterial diversity across surfaces 2025-01-01T00:00:00Z https://hdl.handle.net/10216/165724 Title: A educação em ciências da saúde e a responsabilidade social das universidades 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165714 Title: Integração na profissão: o primeiro passo na formação em ciências farmacêuticas 2024-01-01T00:00:00Z https://hdl.handle.net/10216/165395 Title: Integração e vivências solidárias no ensino superior: contributos de programas de mentoria interpares 2024-01-01T00:00:00Z https://hdl.handle.net/10216/162483 Title: Integrating Metacognition in Physiology Education 2023-11-14T00:00:00Z https://hdl.handle.net/10216/165066 Title: Mentoria Profissional na FFUP estratégia facilitadora da transição para o mercado de trabalho e de redução do abandono académico 2023-07-01T00:00:00Z https://hdl.handle.net/10216/165062 Title: Explorando o "Circuito do Medicamento" como uma estratégia interativa de integração académica para os estudantes do 1º ano de Ciências Farmacêuticas 2024-01-01T00:00:00Z https://hdl.handle.net/10216/164682 Title: Indicadores de higiene e biocidas em superfícies do ambiente de preparação e distribuição de alimentos em unidades de restauração coletiva 2024-01-01T00:00:00Z https://hdl.handle.net/10216/163817 Title: Persistence of mcr-1 carrying Escherichia coli after colistin ban in rabbit farms: implications for One-Health strategies 2024-01-01T00:00:00Z https://hdl.handle.net/10216/162147 Title: Bioprospection of antibiotics and biofilm inhibitors from under-exploited filamentous fungi Abstract: In the past century, antibiotics revolutionized the way infectious diseases were treated, saving millions of lives. However, bacteria, in particular these infectious, may develop antibiotic resistance in such a way that the speed of development of new drugs does not follows the development of resistance. Filamentous fungi have a vast, largely unexplored metabolome, giving them great potential for novel antibiotic discovery. The One Strain MAny Compounds (OSMAC) approach is a valuable tool in this regard and aims to vary culture conditions to obtain a wider range of metabolites. In this study, five under-explored fungal species were used, aiming to identify compounds with antibiotic or antibiofilm properties produced by them. They were grown in different culture media, under deep fermentation for 7 and 14 days, with changing conditions of aeration and agitation, and the resulting supernatants were tested for their antimicrobial activity against Gram-positive and Gram-negative bacteria using the disk diffusion method. All fungi grew on the different media and under the diverse process conditions. It was found that Coprinopsis spilospora metabolites inhibited Staphylococcus aureus growth and demonstrated antibiofilm properties. They reduced the biofilm in 30% in crystal violet staining, metabolic activity by 82% in Alamar blue test, and viable cells counts by 96% in CFU counting. Co-culture and disk diffusion test results also showed that this supernatant has a slight effect against Escherichia coli. The pioneer results obtained in the present study highlight the relevance of bioprospection for antibiotic discovery. 2023-05-12T00:00:00Z https://hdl.handle.net/10216/159061 Title: Invisible dangers on our plates: a critical review of the widespread presence of microplastics and nanoplastics in food 2024-01-01T00:00:00Z https://hdl.handle.net/10216/159053 Title: Assessment of antimicrobial resistance in Gram-negative bacteria from rivers supplying drinking water: insights for water quality management 2024-01-01T00:00:00Z https://hdl.handle.net/10216/159052 Title: A dive into diversity and antimicrobial resistance of Enterococcus from rivers used for drinking water production 2024-01-01T00:00:00Z https://hdl.handle.net/10216/159044 Title: Optimization of DNA Extraction Methods for Metagenomic Analysis in Surface Water Samples 2024-01-01T00:00:00Z https://hdl.handle.net/10216/156134 Title: Genomic Diversity of Klebsiella pneumoniae in Chicken Production Chain: Antibiotic Resistance and Metal Tolerance Interplay 2023-01-01T00:00:00Z https://hdl.handle.net/10216/156133 Title: Uncovering Seasonal Variations in Antimicrobial-Resistant Enterococcus Diversity within Porto Region's Surface Waters 2023-01-01T00:00:00Z https://hdl.handle.net/10216/156132 Title: Long-term persistence of mcr-1 carrying Escherichia coli in intensive rabbit farms after colistin ban 2023-01-01T00:00:00Z https://hdl.handle.net/10216/156131 Title: Assessing Gram-Negative Antimicrobial Resistant Bacteria in Rivers for Drinking Water: A Seasonal Analysis 2023-01-01T00:00:00Z