DSpace Collection:https://hdl.handle.net/10216/267772026-07-10T14:59:32Z2026-07-10T14:59:32ZAprendizagem colaborativa e responsabilidade social das universidades na prevenção do consumo de novas substâncias psicoativashttps://hdl.handle.net/10216/1729642026-04-30T06:19:10Z2025-01-01T00:00:00ZTitle: Aprendizagem colaborativa e responsabilidade social das universidades na prevenção do consumo de novas substâncias psicoativas2025-01-01T00:00:00ZO papel do feedback dos estudantes na avaliação e inovação curricular: uma experiência em ciências farmacêuticashttps://hdl.handle.net/10216/1729592026-04-30T06:12:17Z2025-01-01T00:00:00ZTitle: O papel do feedback dos estudantes na avaliação e inovação curricular: uma experiência em ciências farmacêuticas2025-01-01T00:00:00ZHygiene challenges in foodservice units: biocide efficacy and bacterial diversity across surfaceshttps://hdl.handle.net/10216/1720792026-01-13T07:25:40Z2025-01-01T00:00:00ZTitle: Hygiene challenges in foodservice units: biocide efficacy and bacterial diversity across surfaces2025-01-01T00:00:00ZA educação em ciências da saúde e a responsabilidade social das universidadeshttps://hdl.handle.net/10216/1657242025-03-13T07:22:09Z2024-01-01T00:00:00ZTitle: A educação em ciências da saúde e a responsabilidade social das universidades2024-01-01T00:00:00ZIntegração na profissão: o primeiro passo na formação em ciências farmacêuticashttps://hdl.handle.net/10216/1657142025-03-13T07:21:58Z2024-01-01T00:00:00ZTitle: Integração na profissão: o primeiro passo na formação em ciências farmacêuticas2024-01-01T00:00:00ZIntegração e vivências solidárias no ensino superior: contributos de programas de mentoria interpareshttps://hdl.handle.net/10216/1653952025-02-19T07:20:21Z2024-01-01T00:00:00ZTitle: Integração e vivências solidárias no ensino superior: contributos de programas de mentoria interpares2024-01-01T00:00:00ZIntegrating Metacognition in Physiology Educationhttps://hdl.handle.net/10216/1624832025-02-13T07:21:01Z2023-11-14T00:00:00ZTitle: Integrating Metacognition in Physiology Education2023-11-14T00:00:00ZMentoria Profissional na FFUP estratégia facilitadora da transição para o mercado de trabalho e de redução do abandono académicohttps://hdl.handle.net/10216/1650662025-02-01T07:20:44Z2023-07-01T00:00:00ZTitle: Mentoria Profissional na FFUP estratégia facilitadora da transição para o mercado de trabalho e de redução do abandono académico2023-07-01T00:00:00ZExplorando o "Circuito do Medicamento" como uma estratégia interativa de integração académica para os estudantes do 1º ano de Ciências Farmacêuticashttps://hdl.handle.net/10216/1650622025-02-01T07:20:33Z2024-01-01T00:00:00ZTitle: Explorando o "Circuito do Medicamento" como uma estratégia interativa de integração académica para os estudantes do 1º ano de Ciências Farmacêuticas2024-01-01T00:00:00ZIndicadores de higiene e biocidas em superfícies do ambiente de preparação e distribuição de alimentos em unidades de restauração coletivahttps://hdl.handle.net/10216/1646822025-01-13T07:26:21Z2024-01-01T00:00:00ZTitle: Indicadores de higiene e biocidas em superfícies do ambiente de preparação e distribuição de alimentos em unidades de restauração coletiva2024-01-01T00:00:00ZPersistence of mcr-1 carrying Escherichia coli after colistin ban in rabbit farms: implications for One-Health strategieshttps://hdl.handle.net/10216/1638172024-12-07T07:21:38Z2024-01-01T00:00:00ZTitle: Persistence of mcr-1 carrying Escherichia coli after colistin ban in rabbit farms: implications for One-Health strategies2024-01-01T00:00:00ZBioprospection of antibiotics and biofilm inhibitors from under-exploited filamentous fungihttps://hdl.handle.net/10216/1621472024-10-25T06:18:24Z2023-05-12T00:00:00ZTitle: Bioprospection of antibiotics and biofilm inhibitors from under-exploited filamentous fungi
Abstract: In the past century, antibiotics revolutionized the way infectious diseases were treated, saving
millions of lives. However, bacteria, in particular these infectious, may develop antibiotic
resistance in such a way that the speed of development of new drugs does not follows the
development of resistance. Filamentous fungi have a vast, largely unexplored metabolome, giving
them great potential for novel antibiotic discovery. The One Strain MAny Compounds (OSMAC)
approach is a valuable tool in this regard and aims to vary culture conditions to obtain a wider
range of metabolites. In this study, five under-explored fungal species were used, aiming to
identify compounds with antibiotic or antibiofilm properties produced by them. They were grown
in different culture media, under deep fermentation for 7 and 14 days, with changing conditions
of aeration and agitation, and the resulting supernatants were tested for their antimicrobial
activity against Gram-positive and Gram-negative bacteria using the disk diffusion method. All
fungi grew on the different media and under the diverse process conditions. It was found that
Coprinopsis spilospora metabolites inhibited Staphylococcus aureus growth and demonstrated
antibiofilm properties. They reduced the biofilm in 30% in crystal violet staining, metabolic activity
by 82% in Alamar blue test, and viable cells counts by 96% in CFU counting. Co-culture and disk
diffusion test results also showed that this supernatant has a slight effect against Escherichia coli.
The pioneer results obtained in the present study highlight the relevance of bioprospection for
antibiotic discovery.2023-05-12T00:00:00ZInvisible dangers on our plates: a critical review of the widespread presence of microplastics and nanoplastics in foodhttps://hdl.handle.net/10216/1590612024-06-14T06:18:07Z2024-01-01T00:00:00ZTitle: Invisible dangers on our plates: a critical review of the widespread presence of microplastics and nanoplastics in food2024-01-01T00:00:00ZAssessment of antimicrobial resistance in Gram-negative bacteria from rivers supplying drinking water: insights for water quality managementhttps://hdl.handle.net/10216/1590532024-06-13T06:18:40Z2024-01-01T00:00:00ZTitle: Assessment of antimicrobial resistance in Gram-negative bacteria from rivers supplying drinking water: insights for water quality management2024-01-01T00:00:00ZA dive into diversity and antimicrobial resistance of Enterococcus from rivers used for drinking water productionhttps://hdl.handle.net/10216/1590522024-06-13T06:18:36Z2024-01-01T00:00:00ZTitle: A dive into diversity and antimicrobial resistance of Enterococcus from rivers used for drinking water production2024-01-01T00:00:00ZOptimization of DNA Extraction Methods for Metagenomic Analysis in Surface Water Sampleshttps://hdl.handle.net/10216/1590442024-06-13T06:18:25Z2024-01-01T00:00:00ZTitle: Optimization of DNA Extraction Methods for Metagenomic Analysis in Surface Water Samples2024-01-01T00:00:00ZGenomic Diversity of Klebsiella pneumoniae in Chicken Production Chain: Antibiotic Resistance and Metal Tolerance Interplayhttps://hdl.handle.net/10216/1561342023-12-25T07:18:11Z2023-01-01T00:00:00ZTitle: Genomic Diversity of Klebsiella pneumoniae in Chicken Production Chain: Antibiotic Resistance and Metal Tolerance Interplay2023-01-01T00:00:00ZUncovering Seasonal Variations in Antimicrobial-Resistant Enterococcus Diversity within Porto Region's Surface Watershttps://hdl.handle.net/10216/1561332023-12-25T07:18:07Z2023-01-01T00:00:00ZTitle: Uncovering Seasonal Variations in Antimicrobial-Resistant Enterococcus Diversity within Porto Region's Surface Waters2023-01-01T00:00:00ZLong-term persistence of mcr-1 carrying Escherichia coli in intensive rabbit farms after colistin banhttps://hdl.handle.net/10216/1561322023-12-25T07:18:05Z2023-01-01T00:00:00ZTitle: Long-term persistence of mcr-1 carrying Escherichia coli in intensive rabbit farms after colistin ban2023-01-01T00:00:00ZAssessing Gram-Negative Antimicrobial Resistant Bacteria in Rivers for Drinking Water: A Seasonal Analysishttps://hdl.handle.net/10216/1561312023-12-25T07:17:38Z2023-01-01T00:00:00ZTitle: Assessing Gram-Negative Antimicrobial Resistant Bacteria in Rivers for Drinking Water: A Seasonal Analysis2023-01-01T00:00:00Z